I wonder

I wonder why everyone is so angry about everything.

I wonder why some people get healed from sickness and others do not.

I wonder how many kids I will have, when will I get married.

I wonder what my life will be like for my family in the next 5 years.

I wonder if I will make the right choices.

I wonder if my kids will be happy.

I wonder if my kids will have a good life.

I wonder if there is really someone out there guiding us.

I wonder about God and why things happen.

I wonder if I am going to have a fullfilled life.

I wonder if I am going to do what I am supposed to do.

I wonder what the next step in my journey will be.

I wonder how the universe started.

I wonder how gravity works.

I wonder when I will die.

I wonder why God would allow bad things to happen to good people.

I wonder how the human brain works and how conciousness is possible.

I wonder how concious humans came to exist.

I wonder what the smallest particle is.

I wonder what REALLY makes people happy, content, joyful.

SOMETIMES wonder leads to fear.

SOMETIMES wonder leads to discovery and creativity.

Some of the greatest scientific discoveries started with wonder.

We wonder through lenses and filters.  We wonder through a lens of science and a filter of education.

 

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Migraines in Kids

From here – http://blog.cincinnatichildrens.org/healthy-living/preventing-kids-migraines/

Migraines in Kids: How Can We Best Prevent Them?

OCTOBER 28, 2016

Migraines in kids. How can we best prevent them? That is a question we hoped to answer when began a study that was published in the New England Journal of Medicine this week.

In particular, we wanted to know which preventive medications are the most effective at preventing migraines in kids. With 10% of children under the age of 12 and up to 25% of girls by the time they turn 18 getting migraines, we think it is important information to have.

THE STUDY’S RESULTS

Surprisingly, our study results found that the commonly prescribed preventive medications for migraines in kids – amitriptyline and topiramate – were just as effective as a sugar pill, or placebo.

I am certain that this is going to raise many questions with both parents and physicians alike. The good news is that we know that kids’ migraines can get better with the multidisciplinary therapies applied in this study and the expectation of response (read more about that below) – in addition to the medications. In fact, our study found that those receiving:

  • A sugar pill had a 61% reduction in migraines
  • Amitriptyline had a 52% percent reduction in migraines
  • Topiramate had a 55% reduction in migraines

Neither the two medications nor the sugar pill’s results were statistically different from each other. We got kids with migraines better, but it doesn’t necessarily mean they need to take a medication for that to happen.

WHAT’S INTERESTING ABOUT THE RESULTS

These two aspects – not necessarily medications – appear to have played a more important role in getting kids better:

  • The expectation of a response
  • Non-pharmacologic (drug) therapies

The placebo effect, or the expectation of a response after receiving a sugar pill, was 61% effective at reducing migraines. Patients thought that they would get better, so they did. This study tells us that we need to look further into how we can help kids achieve this without giving them medications (or thinking that they’re being given medications).

THE ROLE OF NON-PHARMACOLOGIC (DRUG) THERAPIES

The other interesting aspect was the non-pharmacologic therapies utilized with all 328 patients across 31 sites nationally. Every patient received acute therapy, healthy habit discussions and help with adherence. Because medications and placebo were equally effective, these other therapies probably played a large role in getting kids’ migraines better.

When we embarked upon this study, we hoped to find a clearer picture for preventing migraines in kids. What we found is that it might not be as simple as prescribing a medication. Our research shows that a more holistic approach incorporating multiple therapies may be the best at preventing them.

So to answer the question, how can we best prevent migraines in kids? With this research, we now know that it’s not a simple answer of which medication to use. It’s more complex of an answer and we plan to study this further to determine which therapies work the best to prevent migraines in kids.

Editor’s note: Andrew Hershey, MD, PhD, pediatric neurologist and co-director of the Headache Center at Cincinnati Children’s, was a co-author of this study.

 

From here – http://blog.cincinnatichildrens.org/healthy-living/preventing-kids-migraines/

 

From here – http://www.nejm.org/doi/full/10.1056/NEJMoa1610384

Trial of Amitriptyline, Topiramate, and Placebo for Pediatric Migraine

Scott W. Powers, Ph.D., Christopher S. Coffey, Ph.D., Leigh A. Chamberlin, R.D., M.Ed., Dixie J. Ecklund, R.N., M.S.N., Elizabeth A. Klingner, M.S., Jon W. Yankey, M.S., Leslie L. Korbee, B.S., Linda L. Porter, Ph.D., and Andrew D. Hershey, M.D., Ph.D., for the CHAMP Investigators*

N Engl J Med 2017; 376:115-124January 12, 2017DOI: 10.1056/NEJMoa1610384

BACKGROUND

Which medication, if any, to use to prevent the headache of pediatric migraine has not been established.

METHODS

We conducted a randomized, double-blind, placebo-controlled trial of amitriptyline (1 mg per kilogram of body weight per day), topiramate (2 mg per kilogram per day), and placebo in children and adolescents 8 to 17 years of age with migraine. Patients were randomly assigned in a 2:2:1 ratio to receive one of the medications or placebo. The primary outcome was a relative reduction of 50% or more in the number of headache days in the comparison of the 28-day baseline period with the last 28 days of a 24-week trial. Secondary outcomes were headache-related disability, headache days, number of trial completers, and serious adverse events that emerged during treatment.

RESULTS

A total of 361 patients underwent randomization, and 328 were included in the primary efficacy analysis (132 in the amitriptyline group, 130 in the topiramate group, and 66 in the placebo group). The trial was concluded early for futility after a planned interim analysis. There were no significant between-group differences in the primary outcome, which occurred in 52% of the patients in the amitriptyline group, 55% of those in the topiramate group, and 61% of those in the placebo group (amitriptyline vs. placebo, P=0.26; topiramate vs. placebo, P=0.48; amitriptyline vs. topiramate, P=0.49). There were also no significant between-group differences in headache-related disability, headache days, or the percentage of patients who completed the 24-week treatment period. Patients who received amitriptyline or topiramate had higher rates of several adverse events than those receiving placebo, including fatigue (30% vs. 14%) and dry mouth (25% vs. 12%) in the amitriptyline group and paresthesia (31% vs. 8%) and weight loss (8% vs. 0%) in the topiramate group. Three patients in the amitriptyline group had serious adverse events of altered mood, and one patient in the topiramate group had a suicide attempt.

CONCLUSIONS

There were no significant differences in reduction in headache frequency or headache-related disability in childhood and adolescent migraine with amitriptyline, topiramate, or placebo over a period of 24 weeks. The active drugs were associated with higher rates of adverse events. (Funded by the National Institutes of Health; CHAMP ClinicalTrials.gov number, NCT01581281).

 

From here – http://www.nejm.org/doi/full/10.1056/NEJMoa1610384

Pray for…

PRAYER FOR A BROKEN HEART

“The LORD is close to the brokenhearted; he rescues those whose spirits are crushed.” (Psalm 34:18)

PRAYER FOR ENCOURAGEMENT

“For I know the plans I have for you,” says the Lord. “They are plans for good and not for disaster, to give you a future and a hope.” (Jeremiah 29:11)

PRAYER FOR HEALING

“Heal me, O LORD, and I will be healed; save me and I will be saved, for you are the one I praise.” (Jeremiah 17:14)

PRAYER FOR SUPPORT

“If God is for us, who can ever be against us?” (Romans 8:31)

PRAYER IN TIMES OF NEED

“Seek the Kingdom of God above all else, and he will give you everything you need.” (Luke 12:31)

PRAYER FOR TOUGH DECISIONS

“Trust in the Lord with all of your heart; do not depend on your own understanding. Seek his will in all you do, and he will show you which path to take.” (Proverbs 3:5-6)

PRAYER FOR FAITH

“I know that my redeemer lives, and that in the end he will stand on the earth.” (Job 19:25)

PRAYER FOR COURAGE

“So be strong and courageous! Do not be afraid and do not panic before them. For the LORD your God will personally go ahead of you. He will neither fail you nor abandon you.” (Deut. 31:6)

PRAYER TO DO THE RIGHT THING

“But even if you suffer for doing what is right, God will reward you for it. So don’t worry or be afraid of their threats.” (1 Peter 3:14)

PRAYER ABOUT FORGIVING OTHERS

“If you forgive those who sin against you, your heavenly Father will forgive you.” (Matthew 6:14)

PRAYER ABOUT SELF FORGIVENESS

“But if we confess our sins to him, he is faithful and just to forgive us our sins and to cleanse us from all wickedness.” (1 John 1:9)

PRAYER FOR STRENGTH

“Don’t be afraid, for I am with you. Don’t be discouraged, for I am your God. I will strengthen you and help you. I will hold you up with my victorious right hand.” (Isaiah 41:10)

PRAYER FOR PEACE

“I am leaving you with a gift–peace of mind and heart. And the peace I give isn’t like the peace the world gives. So don’t be troubled or afraid.” (John 14:27)

PRAYER ABOUT MARRIAGE

“The man who finds a wife finds a treasure, and he receives favor from the LORD.” (Proverbs 18:22)

PRAYER FOR PERSEVERANCE

“No eye has seen, no ear has heard, and no mind has imagined what God has prepared for those who love him.” (1 Corinthians 2:9)

Depression. “Spiritual Definition”

 

From here:   https://gatewaypeople.com/ministries/life/events/individual-messages-2017/session/2017/10/21/what-is-your-refuge

A depressed person is a person who has been going to the wrong refuge for years.

What Is Your Refuge_.mp3

  1. everybody needs a refuge
  2. everybody has a refuge – may just be the wrong refuge
  3. If asked “what is your refuge” – everyone at church would say God… but if I gave you truth serum they would say:  “Money, Visa, Food, Alcohol, Sex, imporality, entertainment, sports, shopping, self pity, self endulgance, self exultation, self promotion, business, relationships, TV, netflix, our minds, my gifts, my strength, my abilitites, tabacco, drugs, etc. ”  <-false refuge.
  4. A “wrong refuge” will:    (Oh – I am going to something else for comfort rather than the comforter)
    1. DISTANCE – wrong refuge will cause distance between you and God – First commandment – you will have no other bods before me. – Going to someone or something FIRST before God.   When you go to the wrong refuge, you are going to another God to meet your needs.  It is called spiritual adultery.  “I just don’t feel close to God…”   But He (God) didn’t move.
    2.  DISSAPOINTMENT – Satan says come over here, YOU will get comfort.  But you never do get comfort.  Instead… you get depressed.  Satan mascarades as an Angel, as a comforter… but there is only one comforter – God.
    3. DESTRUCTION – death.  Spiritual death.

Why do I go to food for comfort.  Cheese talks… “Did you have a bad day?  Come here, let me give you comfort…”

 

Results of choosing the RIGHT refuge…

  1. STRENGTH – when I turn to God I now have strength to overcome what I wanted to turn to.
    1. When do you fall, when do you fail, when do you go back to that thing that you said you would never do…  When you are tired, stressed, anxious about something.  That is when you should go to God to get strength.
    2. When you PRAY about it, you can walk out of the room with peace BECAUSE… YOU GAVE IT TO GOD.
  2. HELP – The Lord is my presence and strength, VERY PRESENT help in my trouble.
    1. Psalm 46:1  — God is our refuge and strength, a very present help in trouble
  3. NO FEAR – in LOVE – God is Love… So there is no Fear IN GOD.   If you have any FEAR, any worry, any anxiety, it is because you are not going to the right refuge.

Here is the problem.  Satan does everything he can to ensure that we do not go to God.

GOD loves you even when you are turning to a wrong refuge.  

Because of who HE is.  NOT because of who you are.  Because of who HE is.

He loves you.

God loves you even if you are turning to drug, alcohol, sex etc. to meet your needs.

He still loves you.

He is waiting for you to return to him.

If you come to God, there is STRENGTH, HELP and NO FEAR.

BECAUSE – Perfect love casts out all fear.

https://www.desiringgod.org/messages/perfect-love-casts-out-fear

Next Step..

Pray – Ask God, in my heart, say “Holy Spirit what are you saying to me in this message. If  there is a place of woundedness, a place of hurt, a place of bondage, a place of fear, a place of worry, a place of anxiety, if you know that through this message, I have been going to the wrong refuge, I want to turn to you.”

3 steps to turn turn back to God:  (Turn back to the right refuge.)  How to get free of wrong refuge.

  1.  realize it
  2. renouce it
  3. repent
    1. change the way you think about alcohol, drugs, etc